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We found that none of the 24 genotypes which have a confirmed association to adult adiposity are associated with birth weight.
A p value of less than 10−4 was considered statistically significant following recommendations that this should be the threshold used for claims of confirmed association when the same SNP has been shown to be associated at genome-wide significance levels in another disease.
10 Recently, a meta-analysis of the Wellcome Trust Case Control Consortium WTCCC GWASandand a US GWAS 4 5 confirmed association to PRKCQ, KIF5A and MMEL and identified additional RA-associated markers mapping to the CD40, CCL21 and CDK6 loci, 11 that have yet to be confirmed in an independent UK population.
Background: Despite of the confirmed association between neck pain and migraine investigations of neck muscles controls in this population is scarce.
We inspected the CHRNA5-CHRNA3-CHRNB4 cluster, the clusterCHRNB3 cluster and CHRNA4, which are genes showing confirmed association to nicotine dependence and smoking behaviours [25 27].
No association was found between degree of suspicion of alcohol and the percentage of individuals with a confirmed association (Table 2).
In this study, there is a confirmed association between cerebral infarction with migraine and Chlamydia pneumoniae infection, but the association between C. pneumoniae IgG antibodies and migraine in the general population has not been investigated.
In addition, we have tested a single SNP at each locus based on previous reports of confirmed association with psoriasis.
Despite a confirmed association between restless legs syndrome (RLS) and end-stage renal disease (ESRD), there is no study on patients presenting with nephrotic syndrome (NS).
We have previously reported on the confirmed association between TNFSF4 alleles with SLE susceptibility and its interactions with several other SLE loci in increasing disease risk [ 2].
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The relatively consistent positive association of risk with birthweight and the well-confirmed association with height (a marker of childhood nutritional status and associated growth factors) strongly suggest an influence of early events, perhaps even those occurring in utero, to subsequent risk.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com