Confirmation of this will be required in other cohorts.
Confirmation in other cohorts will be required to determine the generalisability of this notion.
Clearly, prospective clinical confirmation of this hypothesis will be required, but the preclinical data would support evaluation of such a strategy.
While excess amount of sequence confirmation by Sanger sequencing will be required to confine the candidates to meaningful mutations, simple and cost-effective HRM analysis still provides an easy-to-use platform for mutation screening.
Lastly, our results are based on separated single-arm evidence, and while the considerable amount of data adds to the reliability of our results, confirmations of our findings will be required from randomized clinical trials that report both SVR12 and SVR24.
Support for another three loci, TNFAIP3, TSC1 and RNF114, is provided by evidence of association at nominal p value thresholds of 0.05 although confirmation of association with PsA will be required in other, large datasets.
Larger cohort studies and, as the authors point out, neuropathological confirmation of the imaging findings will be required to fully validate and characterize the binding of these new and essential markers for the in vivo imaging of tau deposits in the brain.
Data from other sources will be required for confirmation of the findings presented.
Although metagenomic approaches were used to quickly annotate various carbohydrate-active enzymes, functional assays will be required for confirmation, since sequence homology does not guarantee functional identity.
