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Hence, these 13,533 compounds were considered as confirmed inhibitors (confirmation rate > 70%) and used in the present study.
Among the confirmed cases, the laboratory confirmation rate ranged from 24.9%% (2009) to 49.5 % (2011).
A total of 767 compounds were confirmed as hits giving a confirmation rate (primary to re-test screen) of 84% and an overall confirmed hit rate of 1.24%.
Finally, out of 29 candidates 14 SNPs have been confirmed which corresponds to a SNP confirmation rate of 48%.
Compounds with ≥25% inhibition in the screen (100, 0.16% hit rate) were cherry picked and confirmed by retesting, with a 73% confirmation rate (Supplementary Table S1).
Despite this careful process, however, when PCPs were contacted to confirm the diagnosis of uncomplicated PUD, the confirmation rate was about 80%.
Finally, 8 out of 9 candidate SNPs were confirmed by Sanger sequencing, supporting a high real positive confirmation rate (0.89).
We confirmed ∼71% of the targets (Fig. 1F a high confirmation rate, considered the magnitude of the observed changes and the sensitivity of qPCR.
All PCR products were Sanger sequenced and subsequent BlastN searches confirmed 71 of 75 predicted Class 1 events, resulting in a sequencing confirmation rate of 94.7% (table 3).
Those with bilateral vestibular schwannoma (VS) alone aged ≥60 years had the lowest confirmation rate (6.6%) and reduced PPV (80%).
"Depending on the final confirmation rate, this could be the slowest tornado year since 1989 when 856 tornados were confirmed," NOAA writes.
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