Although we found statistically significant evidence for association with the CCL21 locus, this would not have remained significant if a correction for multiple testing had been applied and, therefore, confirmation of this locus as an RA susceptibility region will require further investigation in other large data series.
Confirmation of these loci could be accomplished through quantifying segregation in appropriately constructed biparental mapping populations.
Mouse genetic analyses provide a complement to these studies by allowing access to genetic coregulation of molecular phenotypes in tissues that are not available in human clinical studies, and provide independent confirmation of regulatory loci by evaluating conservation of phenotypic association across studies (Belfer et al. 2006; Uhl et al. 2008a).
In addition to the confirmation of the TNF/LTA locus as important for DBLCL risk, examination of the related NFKBIL1 gene on chromosome 6p21.3 revealed intriguing results.
On the other hand, confirmation of existing BMI loci, and detailed analysis on their association with obesity as a binary trait and with other obesity-related quantitative traits, are important at the current stage to move GWAS signals forward and understand their functional consequences.
Ultimately, confirmation of these putative loci will provide new sources of variation for use in soybean breeding programs.
Ultimately, confirmation of the putative loci identified in this study will provide new sources of variation for use in breeding programs developing improved soybean cultivars.
As our study aimed to identify common rearrangements predisposing to RM, previous reports in the DGV database for the prioritized CNVRs of this study were considered as confirmation of true CNV loci, rather than as an exclusion criterion due to unknown reproductive success of the genotyped individuals in these reports.
Here, using an intercross between KK/HlJ (KK) and I/LnJ (I/L) mouse strains reared on standard mouse chow, a cross not previously evaluated for cholesterol levels, we report the confirmation of previously reported loci and the identification of additional, novel QTL controlling HDL and non-HDL cholesterol levels.
Its use allows confirmation of potentially complex multi-locus haplotypes to be resolved by segregation analysis.
