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Consequently, the confirmation of detected differences and further investigation of the impact of related diseases on a biomarker's performance is mandatory.
The advantage of the presented method is the fast, fully tested procedure for confirmation of detected compound in biological samples.
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Using an alternate microarray is a recognized method of confirmation for detected CNVs [ 7, 33].
Quantitative RT-PCR (qRT-PCR) expression confirmation of genes detected as light-regulated by microarray.
Screening to detect signals in the general population and in observational cohorts; Controlled trials for more targeted assessments; Other PRO-AE-based approaches in post-authorisation studies, for instance, the proactive follow-up of patients after occurrence of an AE of special interest (which may include a medical confirmation of the detected events through the event-treating physician).
Polymerase chain reaction and sequencing confirmation of duplications detected by multiple, independent paired-ends showed that paired-end sequencing reliably uncovered the break points of structural rearrangements and allowed us to identify a number of tandem duplications segregating within a natural population.
Furthermore, the support provided by RNA sequence data for analysis of detected DNA variants provides confirmation of potentially druggable mutations.
This strategy of confirmation detected only two errors during the genotyping in MIDIA (2001 2007).
Delivery into X514 cells was confirmed via detecting the kanamycin-resistance gene for pIKM2, while confirmation of pHL015 was detected by visualization of fluorescence signals of secondary host-cells following a plasmid-rescue experiment.
Our confirmation of a previously detected signal of natural selection at FOXP2, and our detection of a novel signal near AHI1, provides some evidence for the hypothesis that genes that appear to be important in syndromes affecting neurological development, also are candidates for selection in the last few hundred thousand years.
On the whole, similarly to the experiments in patient 1, the follow-up paradigms in patient 2 yielded a statistical confirmation of the effects detected with the real-time exploration.
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CEO of Professional Science Editing for Scientists @ prosciediting.com