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We will come back to this while discussing our next topic: a very different Bayesian explication of confirmation, based on the notion of probabilistic relevance.
However, due to the size of the study population and the SLC26A5 gene, previously reported variants assayed by sequencing were only confirmed by a second sequencing reaction either in the opposite direction or in the same direction as the first when deemed necessary for confirmation based on the appearance of the initial sequence electropherogram.
Genes were chosen for real-time PCR confirmation based on the availability of TMGEA, fold change of expression, and expected copy number.
This identification step is based on all subjects in the derivation sample, pooled across the state, province, and country cohorts, with subsequent confirmation based on the re-test validation sample.
In the qPCR confirmation, based on the copy numbers of every individual predicted by RD and qPCR method, we systematically assessed performance of the RD-called CNVs through three evaluation criteria in the process of validation, including the overall agreement rate of RD with qPCR results, the prediction power of RD and the positive prediction rate of RD.
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In addition, while CDC serologic criteria were originally designed for surveillance purposes, laboratory confirmation based on these criteria has been routinely recommended for use in individual, clinical diagnosis by such authorities as the CDC and the Infectious Disease Society of America (IDSA) [ 12, 13].
We present the confirmation, based on Spitzer observations, that the super-Earth HD 97658 b transits its host star.
We present here the confirmation, based on Spitzer transit observations, that the super-Earth HD 97658 b transits its host star.
Serologic confirmation based on a fourfold rise in the level of antibody to the virus in the acute- and convalescent-phase blood samples or the demonstration of an intrathecal antibody response also provides evidence of recent infection.
The DCCT definition of confirmed clinical neuropathy permitted confirmation based on abnormal autonomic nervous system test results.
Putative splicing variants require empirical confirmation based on expression studies from appropriate tissues carrying the mutation, compared with control samples lacking the mutation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com