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9 In the event of a deliberate release of B. pseudomallei, confirmation based on a culture-confirmed diagnosis would provide definitive evidence of case burden, but the same problems of imperfect sensitivity of culture and PCR assays are likely to prevail.
Serologic confirmation based on a fourfold rise in the level of antibody to the virus in the acute- and convalescent-phase blood samples or the demonstration of an intrathecal antibody response also provides evidence of recent infection.
In such cases we believe that existing methods are more robust than LD-based inference, which suffers from the degeneracy of solutions noted above; however, the weighted LD approach can provide confirmation based on a different genetic mechanism.
However, the specimens examined in these studies [ 10, 11] were mostly from France and results require further confirmation based on a more complete and even sampling effort across the current distribution range of the species.
This phenomenon may be related to the greater difficulty of health professionals in peripheral health units to confidently diagnose EPTB; thus, it is necessary to refer patients to other services for diagnostic confirmation or to begin treatment without confirmation based on a high degree of clinical suspicion and negative AFB smear results [ 31].
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Laboratory confirmation based on MAT is a much delayed process, and it is technically challenging, requiring experience laboratory scientists to perform the tests, and the maintenance of live leptospira cultures.
The DCCT definition of confirmed clinical neuropathy permitted confirmation based on abnormal autonomic nervous system test results.
WASHINGTON — In a boon for the Obama administration's efforts to advance the nomination of Chuck Hagel as secretary of defense, Senator Charles E. Schumer of New York told President Obama on Tuesday that he was optimistic that he could vote for Mr. Hagel's confirmation based on his grilling of Mr. Hagel on a variety of issues pertaining to Israel and Iran.
We will come back to this while discussing our next topic: a very different Bayesian explication of confirmation, based on the notion of probabilistic relevance.
Taken together, the absence of peaks representing H4S47C-anchored cleavages across the dyad axis but the presence of peaks representing a single H4 at centromeres provides independent confirmation based on mapping of cleavage positions that single H4-containing particles predominate at centromeres.
Advice is provided about how to step down treatment if needed for diagnostic confirmation, based on available evidence and practical considerations, such as ensuring the patient has a written asthma action plan, and choosing a suitable time (no respiratory infection, not travelling, not pregnant).
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