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We contacted the investigators in several of the studies to confirm trial methodology and to clarify specific outcome data.
We then made a detailed evaluation of each record to confirm trial inclusion (BS and HM, checked by AB).
4 Recent UK data confirm trial recruitment problems in surgery, with only 25% of the 60 current studies recruiting at better than 80% of target (Gower J, personal correspondence, National Institute of Health Research NIHRR) data, 2012).
Though double screening over a two week period is required to confirm trial eligibility, costs for the first screening only are reported with the assumption that only one screening would be performed if BTB is translated for real world settings.
The CONFIRM trial design has been described in detail previously [ 5].
The CONFIRM trial did have a different patient population than the other trials; however, the subgroup analysis of patients who had prior AI therapy ameliorated those differences.
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With the woman's agreement, a letter will be sent to her general practitioner confirming trial entry.
Moreover, the two CONFIRM trials were not addressed to the same patient population.
A prespecified integrated analysis of the randomized, double-blind, placebo-controlled, Phase 3 DEFINE and CONFIRM trials was conducted.
The fMRI data confirm that trial performance was associated with a wide network of cortical and subcortical areas.
If my worst fears are confirmed at trial, with the documents that would be revealed in pre-trial discovery, I believe that a fundamental restructuring of Google would be appropriate.
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CEO of Professional Science Editing for Scientists @ prosciediting.com