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The optimized lead compound was converted to a PEG derivative and a functional in vitro bioassay used to confirm efficacy.
Further evidence is required to confirm efficacy, with long term follow up required to assess the impact of treatment on fracture risk.
The safety of all drugs is established by animal studies, administration to healthy volunteers and the observations during clinical studies to confirm efficacy.
This report presents results from the acute treatment phase of a clinical trial designed to confirm efficacy of a fixed dose of 20 mg of fluoxetine in children and adolescents with major depressive disorder (MDD).
Considering that DVT is more common [14], a study including both conditions could be insufficiently powered to confirm efficacy for PE.
The obtained experimental results performed on the real-life railway crossings infrastructure confirm efficacy and accuracy of the presented anomaly detection method.
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Results confirmed efficacy of the 12 cm heavy water layer designed to suppress reactivity effects in the core.
Emerging data suggest botulinum toxin is an effective treatment for detrusor overactivity (DO), but large studies confirming efficacy and safety are lacking.
Granulocyte function in AS+apocynin mice was suppressed, confirming efficacy of apocynin treatment.
And there is very little pressure for companies (or anyone else) to pursue a phase 3 trial confirming efficacy shown in earlier exploratory trials.
Here, CMR may have a role in confirming efficacy in wider patient groups.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com