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Fourteen or more responses in 26 evaluable patients were required to confirm a response rate of 60% or higher (Fleming-A'Hern design), warranting further evaluation.
This post hoc analysis was also conducted to confirm a response threshold using an anchor-based and supportive distribution-based approach.
Bone marrow aspiration and/or biopsy was conducted before every other cycle for the first 3 months and then every 3 months, at the time of discontinuation and every 3 months during follow-up, and/or as clinically indicated or to confirm a response.
Tumour response was assessed according to RECIST criteria version 1.0 using magnetic resonance imaging (MRI) or computed tomography (CT) on day 21 (±4 days) of every even-numbered cycle, at the end of the study treatment, if disease progression was suspected or to confirm a response.
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The Rovers Trust released a statement on Tuesday morning confirming a response from Mrs Desai, requesting further information on the group's intentions - an apparently significant step given Venky's previous reticence to engage with such requests.
Having confirmed a response to glucocorticoids, we asked whether glucocorticoid treatment in vitro can mimic the improvement in myofibrillar structure evoked by GR activation in vivo in cardiomyocytes.
GAPDH and c-Myc (MYC) were included for reference and to confirm a stress response respectively.
In a study population with 9% syphilis prevalence, Rotchford used linear and categorical modeling to confirm a dose response protective relationship of penicillin on PMR.
To confirm a linear response to exposure time, multiple exposures, ranging from 1 to 10 s, were taken of each EGFP titration measurement.
In addition, H2O2 characteristically causes nucleic acid damage [23] and our data confirm a dose/time response for the presence of 8-OHdG in buccal cell samples.
In addition, only 2 of the 20 (10%) adequately vaccinated participants had post-vaccination testing for antibodies against hepatitis B surface antigen, to confirm a good response and thus an effective protection against HBV infection.
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