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In this context it may be worth remarking that small local confined changes in mechanical properties of a composite material are not likely to affect the overall modulus of the bone material, which is always an average (though not necessarily an arithmetic average) of the local properties.
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For example, PGE1 elicits cAMP accumulation at discrete sites within cells [ 34], suggesting that locally confined, modest changes in cAMP levels, which may be arduous to detect via RIA, may suffice to mediate changes in the activity of downstream effectors such as PKA.
Thus, the global transcriptome change reflected in cluster C2.2 is also strongly associated with antralization, and is likely not confined to changes associated only with the SPEM cell lineage.
Photoisomerization of the film was accompanied by a geometrically confined structural change, as reflected by changes in the electrostatic field.
Despite this, on October 11th Tony Blair carried out his second government reshuffle in three months.Last time, he confined his changes to the ranks of junior ministers.
However, in this rat animal model of lathyrism, the coupled alterations of tissue structural properties make it difficult to weigh the contribution of the anatomically confined material changes to the overall mechanical performance of whole bone.
Porosity changes in response to confining pressure changes were determined by the gas expansion method (Scheidegger 1974; Wibberley and Shimamoto 2005).
The excellent electrochemical performance observed is mainly attributed to the confined volume change of the Sn within the graphene, ensuring the permanent electrical connectivity of the immobilized Sn@graphene anodes.
Owing to the delicate size control and confined volume change within carbon matrix, the Sn@NPC composite can exhibit reversible capacities of 575 mAh g−1 (Sn contribution: 1091 mAh g−1) after 500 cycles at 0.2 A g−1 and 507 mAh g−1 (Sn contribution: 1077 mAh g−1) after 1500 cycles at 1 A g−1.
However, we cannot rule out changes that would be masked by the dilution effect of non-recombined cells, changes confined to specific cellular compartments, or changes that might be more apparent later in development.
For now, though, I'm confining my changes to Virginia, where the race has always been pretty tight, and Colorado, where polls suggest Romney has enjoyed a big tick upwards in recent days.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com