To further elucidate the relationship of the 195 clusters, we ran CLANS 100 times with a random initial configuration of the sequences in 3d space.
Instead, several RATYs are flanked by inverted REP sequences, that is, 5′ to 3′ configuration of the REP sequence on the side of the transposase gene encoding the amino terminal end and a 3′ to 5′ REP configuration on the side encoding the carboxyl terminal.
The scheduler approach allows re-configuration of the sequences without altering the implemented controller.
These strategies can be used to synthesize the alternative intensified configurations from the simple column configuration of the separation sequence.
In ATXN2, polyQ expansions of ≥34, which are pure CAG repeat expansions, cause spinocerebellar ataxia type 2. However, similar length expansions that are interrupted with other codons, can present atypically with parkinsonism, suggesting that configuration of the repeat sequence plays an important role in disease manifestation in ATXN2 polyQ expansion diseases.
We have developed an in vivo model in which BALB/c mice synthesize DNRAbs following immunization with a configuration of the consensus sequence multimerized on a polylysine backbone (termed MAP-DWEYS), while BALB/c mice immunized with the polylysine backbone alone (MAP-core) do not (Kowal et al., 2004).
As in the subsection "Methods", we introduce the variables z ij defined as follows: z ij (for 1≤iConfiguration j in the sequence of configurations.
This approach links the gene activation probability to all possible molecular configurations of the regulatory sequence, representing different combinations of free and bound binding sites.
In order to improve the thermal properties of thus obtained materials, triblock copolymers: PTMC-b-PDLA-b-PTMC and PTMC-b-PLLA-b-PTMC of the opposite configuration of PLA sequence, have been used for the preparation of the corresponding stereocomplex.
These hypotheses can be tested because they make different predictions regarding the sequence configuration of the asymmetric ISWpi1 TIRs, which are identical 23 bp-long sequences except for a single A/T nucleotide mismatch corresponding to nucleotide position (np) 17 in the left TIR [19].
