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Only the six cysteine residues responsible for conferring structure are conserved across all the relaxin-like peptides.
Glycosylation is a posttranslational modification of proteins playing a major role in cell signalling, immune recognition, and cell-cell interaction because of their glycan branches conferring structure variability and binding specificity to lectin ligands.
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But it is now widely acknowledged, even by minimalists, that at the very least some higher-order relations are needed to confer structure on first-order properties.
All primate amelogenin proteins are enriched in amino acid residues that promote disorder and depleted in amino acid residues that confer structure to a protein [19].
The mutant rats were known to have impaired splicing of titin, a sarcomeric protein that confers structure and function to striated muscle.
The composition of polysaccharides and their sulfation content confers structures on the cell surface which determine the binding of a number of ligands to the cell surface [4].
Helical structures could have conferred structural stability to the proto-adapters (tRNA precursors), possibly for coding functions.
They are the molecular machines and building blocks in the human body that drive or exert most biological functions and confer structure and function to cell and tissue architecture.
To determine if extension of this polypeptide would confer secondary structure content and/or stability, 20 residues were added to the C-terminus of apoA-I(1 172) by EPL, creating apoA-IMilano(1 192).
One dimension that can confer additional structure to the system is time, and the timing/duration of signaling and gene expression responses is likely to influence the cellular response.
The conformational constraints of the proline cyclic side chain confers secondary structure beneficial for proper alignment of residues within binding motifs.
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