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SATB1 has been suggested to have an indirect role in conferring competence for Xist silencing within the developmental window of opportunity (Agrelo et al., 2009).
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In her world, youth is still callow; age still confers competence and wisdom.
Competence in the Pasteurellaceae is under the control of a number of genes, all of which must presumably be fully functional in order to confer competence.
However, the approach used for mouse ESCs did not confer competence for germline fate on hESCs.
JH also confers competence to fat body cells and ovarian follicles for uptake of ecdysteroidogenic hormone (OEH).
Of the vision related genes highly biased in M. davidii IKZF1 encodes a transcription factor called Ikaros family zinc finger 1, an ortholog of which confers competence to mouse retinal progenitor cells (Elliott et al. 2008).
Helicobacter felis lacks a Cag pathogenicity island and the vacuolating cytotoxin VacA but possesses a complete comB system conferring natural competence.
Supporting this idea, 'stand-by' occupancy of regulatory regions by pioneer transcription factors precedes activation of developmentally-controlled genes, conferring transcriptional competence [ 41– 41].
Although snoRNAs may not be essential for conferring coactivator competence to the recombinant DKC1 complexes, we note that the endogenous DKC1 complexes are twofold to threefold more active than their recombinant counterparts, suggesting that some mammalian snoRNAs may play a role in enhancing the transcriptional activity of the DKC1 complex.
Knowing what we all know now, and especially if SNP MPs seek to block an EU referendum, there may be less of an appetite in Westminster to confer that competence.
A particularly interesting, and perhaps less well known and underappreciated, application of Flp in revealing unique DNA topologies required to confer functional competence to DNA protein machines is discussed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com