These structures go some way to delineate specific interactions that confer specificity for the adenine base and RNA, and show that these specificities are caused by rather small tweaks in the helicase core.
Alternatively, it is possible that TolC can form a functional pump by interacting with CusAB, but that specific structural features of CusC would confer specificity for monovalent cations (e.g. by having a narrow channel).
Therefore, spatio-temporal differences in expression of the investigated proteins or the presence of other actin-binding proteins that have evolved class-specific interactions (Kandasamy et al., 2007) might confer specificity to ACT-AIP1 interaction in vivo.
BAF250a has a DNA-binding domain that specifically binds to AT-rich DNA sequences and is thought to confer specificity to the complex [Wu et al., 2009].
Leal (2013) stated that male moths detect sex pheromones with tuned odorant receptors, which confer specificity to peripheral odorant receptor neurons, with the assistance of other olfactory proteins.
Signal transducing guanine nucleotide binding (G) proteins are heterotrimers with different alpha subunits that confer specificity for interactions with receptors and effectors.
Residues, especially Phe32 and Val36, from this structured N-terminus contact the hydrophobic groove in the D3 domain of the receptor and help confer specificity towards the c-isoforms.
On the other hand, FSNPs by themselves are not selective for cancerous tissue, so researchers have turned to aptamers to confer specificity and selectivity on FSNPs biodistribution and activity.
This structure determination was undertaken to establish the stereochemical features in the antibody binding site that confer specificity for cocaine, and as part of an ongoing project to understand the rules that govern molecular recognition.
This review will describe recent progress in the development of 'user-targetable' systems, particularly highlighting the application of custom DNA-binding proteins or nucleic acid homology to confer specificity.
Rab proteins are small GTPases that confer specificity to membrane fusion events in the endosomal pathway.
