Sentence examples for confer predisposition from inspiring English sources

Minor defects in the NHEJ pathway moreover have been shown to confer predisposition to leukemia.

As for NHEJ, genetic polymorphisms influence DNA repair capacity and confer predisposition to several cancers, including skin [ 12], breast [ 13- 15], bladder [ 16, 17], and oral cancers [ 18, 19].

Beyond the radiation field, radiotherapy may increase the risk of lung and breast cancers through the bystander effect, in which the non-exposed cells receive signals from irradiated cells (radiation-induced genomic instability) and confer predisposition to malignancy [ 38].

Further research is necessary to identify the specific minisatellite variants that confer predisposition and to further evaluate the associations between hTERT-VNTR2-2nd alleles and cancers of the prostate.

IAS is relatively common in Japan, where it is the third leading cause of hyperinsulinemic hypoglycemia probably due to the high prevalence of HLA alleles that confer predisposition to this syndrome (5).

To date, several genome-wide association studies (GWAS) have identified specific genetic loci, such as HLA-B*5701 HLA-B*57011 HLA-A*0201 HLA-A*0201andconfer predisposition to liver injury from the drugs flucloxallicin, amoxicillin and clavulanate, respectively [ 8, 9].

This is the first report showing a small number of GAS M types conferring predisposition to pyoderma by diverse types.

In hereditary cases (40 45% of cases) there is a germline mutation of RB1, thereby conferring predisposition, and the second allele is inactivated by somatic mutation.

The first mutation (M1) is germinal and confers predisposition to the hereditary type, which is transmitted as an autosomal dominant highly penetrant trait, so 90%% of carriers develop retinoblastoma; however, 10%% of carriers either do not develop the tumor or develop it unilaterally.

The genes possibly conferring predisposition to the clinical association of T2D, MetS, and depression are the CRHRs (CRHR1 and CRHR2), the corticotropin receptors or melanocortin receptors (MC1R– MC5R), the glucocorticoid receptor (GCR), the mineralocorticoid receptor (MCR), and the FK506 binding protein 51 (FKBP5) (Table 1).

As this set of patients was enriched with ovarian cancer cases and due to the low frequency of RAD51C mutations, other studies must be conducted in larger series to evaluate whether RAD51C confers predisposition to ovarian cancer alone or to both breast and ovarian cancer, which remains controversial [ 42].