2) In the Discussion, the authors describe miR-92 as conferring negative feedback on the oncogenic activity of miR-17-92 miR-17-92 miR-17-92
Both negative effects can be attributed to sugar catabolism conferring negative feedback on the pathway similar to negative feedback in transcriptional circuits.
VosA potentially functions as both an activator (for wetA, tpsA and orlA) to complete sporogenesis and a repressor (for brlA and treA) to confer negative-feedback regulation.
In response to Shh signalling, cells steadily upregulate Ptc1, as well as other inhibitors of Shh signalling, conferring a negative feedback loop to the pathway.
In summary, the results suggest that a multiple negative feedback loop structure confers desirable properties through enhancing sensitivity to both qualitative and quantitative changes of the photo-profiles and their robustness to noisy external fluctuations.
Classically, negative feedback structures are considered to confer stability, while positive feedbacks tend to have the opposite effect.
Therefore, mir-17-92 encodes an internal component to confer a negative regulatory feedback on its oncogenic activity, imposing a strong selection for anti-apoptotic lesions to shape the path of malignant transformation.
Furthermore, continuous exposure to first-generation inhibitors can confer overexpression of HER3 as a result of loss of AKT-mediated negative feedback signaling [ 50].
The dual positive and negative feedback loops drive the sustained oscillation of gene expression of individual cells, and in the meantime, the signaling molecule AHL confers the synchronization of individual oscillations.
Despite the negative feedback, he persevered.
NNF: Negative feedback loop with additional negative feedback loop.
