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In keeping with the epidemiological data and polygene score analysis, many of these loci appear to confer liability to both schizophrenia and bipolar disorder [ 8].
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25 It is possible that the genetic variation that confers liability for postpartum haemorrhage acts through one or more of these biological processes.
The same genome scan for AN was subsequently used to increase the likelihood of finding genetic variation conferring liability to eating disorders.
Some population based twin studies suggest at least some of the genes conferring liability differ between the sexes [ 7] while others do not [ 8].
Thus, the autoimmune signature may confer a liability for development of disease, while the specific disease syndrome that develops is likely dependent on additional factors that might include other genes or environmental stimuli like microbes or hormones [ 25].
Overall, these results complement growing evidence suggesting that 5HTTLPR confers liability for ADHD that is activated in particular environments, rather than conferring risk for ADHD directly.
The gene, which could be referred to as TCO because it confers a liability to oncocytic follicular cell tumour development, is likely to be involved in at least some sporadic oncocytic tumours.
The fact that oncocytic tumours can be both multiple and familial strongly suggests that there is a germline mutation conferring an increased liability to develop this type of thyroid tumour.
A hallmark of nascent hybrid and polyploid genomes compared with that of a pure-line is their liability to change, which may confer enhanced evolvability compared to that of a pure-line [ 41, 43].
This chemical group has been shown to confer selectivity against other protein kinases but at the expense of a metabolism liability.
With few exceptions, individual risk loci confer only a modest effect on disease susceptibility and together, the known loci explain ∼13% of variation in disease liability [59].
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