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Mutants of eEF1A in S. cerevisiae have previously been shown to confer independence from eEF1Bα: R164K, T22S, A112T, and A117V [ 24].
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A good job confers independence and pride; it strengthens families; it broadens the opportunities and horizons for children.
This is true in the region's two biggest economies, Brazil and Mexico, but not only there.Brazil's constitution, enacted in 1988, conferred independence on the public prosecutor's office and the judiciary.
Importantly, Gab2 also conferred independence of the morphogenetic program from exogenous EGF and intrinsic EGFR kinase activity [ 39].
It is likely that there are additional Tfe3 targets because TET cells self-renew without requirement for either MAPK or GSK3 inhibition, whereas forced expression of Esrrb confers independence only from the latter (Martello et al., 2012).
A third mutation conferring independence from the kinetoplast, γA273P (in this case, ectopically expressed in a single endogenous knockout background) (9), showed resistance to EtBr similar to that of the γWT-expressing cell line.
These findings strikingly reveal an independent capacity of endogenous cyclin D1b to confer serum independence, consistent with capacity of cyclin D1b to drive tumor formation in vivo.
Fresh and marine waters provide abundant calcium but only traces of phosphate; because relatively high levels of phosphate are characteristic of the body fluids of higher vertebrates, it seems likely that a large, readily available internal phosphate reservoir would confer significant independence of external environment on bony vertebrates.
Thus both the Eastern and Western Regions of Nigeria are expected to become independent this year, and though, in default of the Northern Region following suit, this will not automatically confer full independence on Nigeria as such, the handling of its affairs at a "higher level" than the Colonial Office may well be put forward as a compromise in the delicate constitutional negotiations in May.
EGFR-SEPT14 fusions activate STAT3 signaling and confer mitogen independence and sensitivity to EGFR inhibition.
Of the seven mutations that differentiate iMac239 from wild-type SIVmac239, a single change (D178G) in the V1/V2 region was sufficient to confer CD4 independence in cell-cell fusion assays, although other mutations were required for replication competence.
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