Sentence examples for confer gain from inspiring English sources

Disruptive mutations are selectively associated with allelic loss of wild-type p53,(32) and confer "gain of function" phenotype.

The first indication that truncation of chordin could potentially confer gain in function was observed in Drosophila [ 21].

Missense mutations of p53 have been shown to confer gain-of-function phenotypes compared to p53 null mutations [27], [35].

The second approach was based on the idea that missense mutations of p53 confer gain-of-function phenotypes and possibly alter tissue specificity, favoring the development of carcinomas [27], [35].

Although identified in the context of drug resistance, emerging data suggest that the T790M change may potentiate oncogenic activity, either by itself or in association with alterations in the EGFR kinase domain already known to confer gain-of-function properties [7] [9].

Does the mutation confer gain-of-function, loss-of-function, or a new functionality altogether?

By contrast, the mechanism by which the V550L and V550E mutations confer gain-of-function is not fully understood.

According to our structure, the N535K or N535D mutations confer gain-of-function by disengaging the autoinhibitory molecular brake at the kinase hinge region.

Oncogenic mutations in ras genes confer gain-of-function by providing constitutive activation that drives uncontrolled cell proliferation and malignant transformation.

This domain has been demonstrated to exert an important negative regulatory function on the kinase domain [ 15] with many of the amino acid changes we identified falling into positions of JAK1/3 reported as being mutated in human leukemias, and shown to confer gain-of-function or transforming activity (Fig.  2e) [ 16– 16].

Site-directed mutagenesis of this residue confers gain or loss of VH3 F(abindingnding to these resins in 3 mAbs, demonstrating that it plays a key role in both recombinant protein A and Z domain interaction.