Sentence examples for confer acquired from inspiring English sources

CRISPR arrays and associated cas genes are widespread in bacteria and archaea and confer acquired resistance to viruses.

Increased expression of AEBP1 is shown to confer acquired PLX4032 resistance by facilitating activation of NF- κB.

These elements function via small RNA molecules to confer acquired immunity, in a way that may recall piRNA clusters.

Despite numerous studies revealed that double mutations confer acquired imatinib resistance in GISTs, we (in this study) and others (Antonescu et al, 2005; Wardelmann et al, 2006) found a proportion (40 53%) of imatinib-resistant GISTs harbouring a single KIT mutation, suggesting the involvement of alternative resistance mechanisms.

The EGFR T790M mutation confers acquired resistance to kinase inhibitors in human EGFR mutant lung adenocarcinoma, is occasionally detected before treatment, and may confer genetic susceptibility to lung cancer.

A secondary mutation of the EGFR gene reported in 2005 conferred acquired resistance to EGFR-TKIs.

We next determined whether upregulation of AEBP1 expression confers acquired PLX4032 resistance to melanoma cells.

In addition, our finding suggests that P-gp confers acquired resistance to imatinib by functioning as an efflux transporter and reducing imatinib accumulation.

Importantly, we find a positive mutual regulation between Cx26 and PI3K/Akt pathway, which confers acquired gefitinib resistance in NSCLC cells by GJIC-independent induction of EMT.

Here we report that increased expression of AEBP1 (adipocyte enhancer-binding protein 1) confers acquired resistance to BRAF inhibition in melanoma.

Recently, two related papers demonstrated that nuclear EGFR confers acquired resistance to an EGFR-TKI, gefitinib, by increasing the expression of breast cancer-resistant protein (BCRP), which is an ATP-binding cassette transporter that pumps anti-cancer drugs out of cells [ 17, 64].