EGFR mutations conferring a response rate to erlotinib higher than 50%, according to the EGFR somatic mutations database (http://www.somaticmutations-egfr.info/), were also added.
The observation that multiple copies of Chk1D469G confer a checkpoint response whereas multiple copies of Chk1D469A do not, led us to consider the basis for this allele specific response and examine the behavior of the two mutant proteins more closely.
Mutational analyses of the HIV-1 LTR have demonstrated that this set of transcription factor binding sites is especially suited to confer a high response to the Cyclin T1/p-TEFb complex when it is recruited to the viral LTR via Tat and TAR RNA [64] [67].
However, immunisation with C. gattii cell wall or cytoplasmic components can confer a protective response to subsequent C. gattii infection (Chaturvedi et al., 2014).
With an effective iterative procedure in hand we investigated its utility through the synthesis of targeted sensors for Zn2+ based on metal binding units previously reported to confer a selective response to zinc and a selection of readily available biological targeting units.
The finding that the population at greatest risk for relapse if they had active disease caused by a Beijing genotype was persons of Asian Pacific Islander race/ethnicity suggests that the coevolution of this bacterial strain and the human population may have selected factors that confer a poor response to therapy.
The increased proliferation associated with elevated Bax expression could confer an improved response to radiotherapy in patients with high Bax.
Thus, intestinal expression of Pdx1, MafA, and Ngn3 drives the formation of ectopic insulin-producing cells that confer an improved response to glucose challenge without fasting hypoglycemia.
Despite the increasing evidence that IL-6-induced pro-oxidant production could confer an adaptive response in normal tissues, the relationship between IL-6-mediated resistance to oxidative stress and myeloma cell resistance to therapy is unknown.
Moreover, it is possible that the downregulation of growth-promoting molecules and the upregulation of the TGF-β3 signaling pathway may work in concert with one another, as well as other factors, to confer an altered response to subsequent proliferative stimuli.
The phosphorylation state of the response regulator DegU also does not confer a straightforward "on/off" response; it is fine-tuned and at different levels triggers different sub-regulons.
