Therefore there is no doubt that gene duplication is extremely pervasive, conducting function in almost all organisms from prokaryotes to eukaryotes [ 9, 13].
The nose and oral cavity are mainly static in their conducting function, whereas the pharynx and larynx predominantly are muscular structures and thus may alter the patency of the upper airway [ 15, 25].
Well-structured functional knowledge Is essential to conduct function design as stated by well-known design methods, Including Suh's axiomatic design approach and one of Pahl and Beltz.
DAVID was used to conduct function and pathway enrichment.
To obtain an overall view of the potential function of polymorphisms within gene fragments, we analyzed the SNP frequency distribution and conducted function prediction with PolyPhen (Ramensky et al. 2002).
Next, we mined the three-way gene interactions (motifs), and then conducted function enrichment analysis of gene-gene and three-way gene interactions to find out the global characteristics related to disease pathogenesis.
The role of N-glycans attached to the Kv3.1 glycoprotein on conducting and non-conducting functions of the Kv3.1 channel are quite limiting.
In this study, we have demonstrated that N-glycans of the Kv3.1 glycoprotein influence conducting and non-conducting functions of the Kv3.1 channel.
Further dysfunction and expression levels of these channels have been linked to diseases of the nervous system [8] and cancer [9], and therefore the modulation of conducting and non-conducting functions of the Kv3.1 channel is of considerable medical interest.
Therefore, transfected B35 cells are a feasible neuronal-derived cell expression system to evaluate the role of the Kv3.1 protein with two, one, and zero N-glycans on conducting and non-conducting functions of the Kv3.1 channel.
We speculate that the expression of specific Kv3.1 glycoforms may influence action potential waveforms, and furthermore that some patients suffering from congenital disorders of glycosylation may have altered conducting and non-conducting functions of the Kv3.1 channel.
