Statistical analysis was conducted with Fisher exact test for frequency data.
Statistical analyses were conducted with Fisher exact tests and epidemiologic tabulations in Stata version 8.2 (Stata Corp., College Station, TX, USA).
If the asymptotic model did not converge, analyses were conducted with the exact inference methods (Mehta et al, 1985) for contingency tables implemented in the EPIXACT software (Cytel Software Corporation, Cambridge, MA, USA).
Based on miRNA-gene regulations, given one miRNA, a module will be regarded to be regulated by this miRNA if its target genes are significantly enriched in this module, where the enrichment analysis was conducted with Fisher exact test with P-value cutoff of 0.01.
Conducted with Fisher's exact test and Benjamini-Hochberg corrected p-values, which were Z transformed (e.g. p = 0.05 ≜ Z = 1.96).
Comparison of other infection-related parameters, such as prescription of antibiotics and number of additional visits, was conducted with Fisher's exact test and Mann-Whitney U tests, respectively.
Statistical analyses comparing the ratio of colonized tumors between experimental groups were conducted with Fisher's exact test to determine two-tailed P values using Prism 5.0 (GraphPad software Inc .. Data were considered significantly different when P < 0.05.
Univariate analyses were conducted with χ or Fisher exact tests for categorical variables and the Kruskal Wallis test for continuous variables.
For a general characterization of ovary- and testis-specific genes, Gene Ontology (GO) term enrichment analysis was conducted with the Fisher's exact test in classic algorithm of topGO (Alexa and Rahnenfuhrer 2010).
To determine significantly enriched protein domains associated with the AS occurrence, Fisher's exact test was conducted with a p-value cutoff of less than 0.05.
