As no differences between the European parasite populations could be inferred from this analysis (Additional file 1), these populations were pooled and the next set of fixed-effects linear models was conducted (Additional file 2).
Correlational analysis and principal component analysis (PCA) were conducted (Additional file 2: Table S3).
In order to optimize the preparation parameters, a Box-Behnken design (BBD) was conducted (Additional file 1: Figure S5).
The pH value of tumor microenvironment is acid, so drug accumulation release rate in PBS (pH 5.5) was further conducted (Additional file 1: Figure S5).
To achieve an overall view on the distribution of putative cis-elements in the promoters of the differentially expressed genes in rad mutant, the motif enrichment analysis was conducted (Additional file 1).
Two set of experiments were conducted (Additional file 4: Exp 4).
LAS carried out a portion of the exposure assessments, conducted DEP file reviews, conducted analyses, and wrote the initial draft of the manuscript.
Effect modification by body mass index [ 27] and country were assessed, and several sensitivity analyses were conducted (Additional file 1).
In the baseline study, 49 in depth interviews (IDIs) and five focus group discussions (FGDs) were conducted (Additional file 1).
Missing at random was thus a plausible conclusion and multiple imputation was subsequently conducted (Additional file 1).
