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Prolongation of the QRS complex reflects the presence of intraventricular conductance abnormalities, such as bundle-branch block, decreased ventricular conduction velocity and/or ventricular hypertrophy.
To examine if the observed conductance abnormalities predispose FFFRs to cardiac arrhythmias, we evaluated both functional and electrophysiological characteristics of Langendorff perfused hearts, before, during and following 30 min of LAD occlusion.
Mice engineered to over-express tumour necrosis factor-α have been commonly used as a model of congestive HF, exhibiting a large number of ion channel conductance abnormalities and increased susceptibility to induced arrhythmias compared to wild-type controls [ 147– 147].
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QRS prolongation represents a conductance abnormality, which may be explained by decreased conductance velocity in the ventricles.
Although class III mutations possess minimal to no CFTR-dependent transport, class IV defects represent abnormalities of chloride conductance and may have partial activity in vivo.
EndMT contributes to cardiac fibrogenesis which results in progressive stiffening of the ventricular walls, loss of contractility, and abnormalities in cardiac conductance [ 32].
These techniques have been applied to neurodegenerative disorders including motor neuron disease, and have established functional abnormalities of persistent Na+ conductances and K+ ion channel function (Bostock et al., 1995; Mogyoros et al., 1998; Kanai et al., 2006; Vucic and Kiernan, 2006).
To determine whether primary sclerosing cholangitis (PSC) in childhood is associated with abnormalities in cystic fibrosis transmembrane conductance regulator (CFTR).
Cystic fibrosis (CF) is a genetic condition that is caused by abnormalities in the CF transmembrane conductance regulator (CFTR) gene.
Our data support the conclusion that loss of CatSper conductance is rare, may occur independently of abnormalities associated with spermatogenesis and, importantly, has functional significance.
These mutations include the Arg117His CFTR missense mutation that causes mixed conductance (class IV) and gating (class III) abnormalities, which is responsible for around 2%% of CFTR mutations in northern European populations [ 49].
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