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In other words, in very specific situations, it can be effectively illegal under UK law to conduct a replication study.
Eventually, we did not conduct a replication study, which is highly desirable with association studies.
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We initially genotyped the NHS, and then conducted a replication study in the HPFS.
We then conducted a replication study in an independent cohort of adult patients with a history of childhood APN.
We therefore conducted a replication study with a candidate gene approach to validate this finding by genotyping 28 common SNPs within MERTK in an independent cohort of 1140 MS cases and 1140 healthy controls.
Based on association analysis of directly genotyped and imputed SNPs in the discovery dataset, we conducted a replication study with a candidate gene approach focusing on 28 SNPs within the MERTK gene.
For this novel locus, we conducted a replication study using 225 Korean subjects with distal colon cancer and 377 controls.
We conducted a replication study in different cohorts to assess the effect of rs133885 maths-related measures.
In view of these inconsistent results, we conducted a replication study, because replication is strongly recommended by statisticians as the best validation strategy [ 27].
Designing and conducting a replication study does not require access to raw data from the original study; this would abrogate the concept of independence.
To test the reliability of these findings, we next conducted a replication study using an independent sample of 28 new participants (16 female) drawn from the same demographic group (see Experimental Procedures).
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