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The model was validated with experiments designed with different initial conditions of nutrients and input changes, and showed good agreement with experimental observations.
Before the experiment, batch cultures of each genotype were acclimated to experimental conditions of nutrients and light for four weeks in 150 ml flasks filled with 100 ml of medium.
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Therefore, the metabolic benefits of browning may be unveiled predominately under the conditions of nutrient excess.
PHB is an intracellular storage compound produced by many organisms under conditions of nutrient limitation (N, P, etc).
Members of the AMPK/Snf1 family in the mammalian system are generally associated with cell survival under conditions of nutrient starvation [25].
Additionally, Tlili et al. (2010) demonstrated the shift in the microbial community in response to toxicants such as Cu and diuran (herbicide), especially in conditions of nutrient deficiency.
Moreover, several studies in higher eukaryotic systems documented the essential role of sirtuins for maintenance of autophagy during conditions of nutrient starvation [58], [59].
Kss1 is the MAP kinase that primarily functions under conditions of nutrient deprivation such as the lack of nitrogen or glucose in the growth media [15].
Transient exposure to niclosamide, perhexiline or rottlerin causes reversible inhibition of mTORC1 signaling and is not toxic to cells in conditions of nutrient and growth factor sufficiency.
GLS-H and mDHFR confer a metabolic phenotype to each of the two attractor, since these enzymes compensate for two distinct conditions of nutrient depletion.
This emerging molecular scenario outlined by these observations would allow cells and organisms to react specifically to different conditions of nutrient availability and food composition.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com