CLOVE allows the dynamic creation of view classes based on complex logical conditions, supports inheritance of views, and also incorporates user role definitions and access rights.
Cassa et al. similarly included in their study a broader range of conditions and inheritance modes (and thus diagnostic triggers for reporting an IF) than the specific set of 24 conditions defined in the ACMG recommendations; ~24% of their reported conditions were homozygous minor variants.
A will may be considered invalid if, among other instances, the testator was mentally incapable of disposing of his property; if the will imposed unreasonable or cruel demands as a condition of inheritance; or if the testator did not have clear title to the bequeathed assets.
It is recommended that all assertions of pathogenicity (including "likely pathogenic") be reported with respect to a condition and inheritance pattern (e.g. c.1521_1523delCTT (pathogenicl), pathogenicystictic fibrosis, autosomal recessive).
For Darwin, while natural selection was the outcome of the inevitable conflict created by the conditions of existence, inheritance was the explanation for the natural classification.
In contrast to recessive conditions with biallelic inheritance, identification of dominant (monoallelic) mutations for Mendelian disorders is more difficult, because of the abundance of benign heterozygous variants that act as massive background noise (typically, in a 400 1 excess ratio).
Under such multi-factorial inheritance conditions, it is plausible that family history is a mutable risk factor.
One of the strongest risk factors for many birth defects is a family history of the same defects; this reflects both genetic and environmental risks for conditions with complex inheritance patterns, and, as a result, it has been hypothesized that many birth defects have both genetic and environmental influences.
As in other fields, two main strategies have been adopted: one is to study rare familial pain conditions with Mendelian inheritance patterns, the other to use either candidate-gene or genome-wide association studies (GWASs) to identify polymorphisms that segregate with complex pain disorders (see [ 17] for a review).
In court papers, Jerry Dier claimed his wife had told him that she was seeking the divorce only because her family was demanding it as a condition of her inheritance.
