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Polypharmacology has been increasingly advocated for the therapeutic intervention in complex pathological conditions, exemplified by cancer.
A considerable literature is available in the fields of invertebrate biochemical and ecophysiological adaptation to extreme environmental conditions, exemplified by those of the Antarctic.
The sweeping algorithm removes modules that have a large overlap with another module, but only show dependent co-expression across a smaller subset of conditions (exemplified in Fig. 3).
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Our findings that loss of Plrx function does not affect parasite development under normal growth conditions exemplifies the important role of reverse genetics in guiding drug development against malaria.
The profound changes in hepatic lipid handling in tumour-bearing mice therefore prompted us to screen for the dysregulation of distinct transcriptional co-factor gene expression under cachectic conditions, exemplifying nuclear receptor, inflammatory and hormonal (glucocorticoid) signaling in liver.
Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition exemplified by the identification of a subgroup of COPD subjects with eosinophilic airway inflammation [ 1, 2].
Burn severity polygons on this final version (modified based on spot field evaluation of soil condition) exemplifies the greater detail and resolution possible by this improved method.
Yet, theoretically, conditions could be fulfilled under certain ecological conditions, as exemplified by the Iberian minnow Squalius alburnoides where the proportion of tetraploids varies markedly between populations living in different habitats [ 18, 93].
And these conditions are exemplified by what the UN has identified as the poorest city in the world, Monrovia, the capital of Liberia.
The architecture of the trained ANN for accurately simulating thermal behaviour of LiFePO4 pouch cells of the nominal capacities from 8 to 20 Ah under varied conditions is exemplified.
While the G7 Summit is very unlikely to usher in any big new initiative in the climate arena, the rapid and serious deterioration of planetary conditions, as exemplified by the bush fires in Alberta and record temperatures in India, makes the necessity to stay under a 1.5C rise a moral issue.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com