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The assay was performed under universal conditions as previously described (Ashton et al., 2008).

The hollow ZIF-8s with excellent crystalline structures were obtained via a mild phase transformation under solvothermal conditions, as previously reported34.

Membranes were processed under sterile conditions, as previously described by Tseng et al. (1998).

To measure hemodynamic parameters, we inserted two vascular catheters under sterile conditions as previously described [20].

Rodent MSCs (MSCs) were isolated from rat femora and tibiae under sterile conditions as previously described [14].

Shake flask fermentation was conducted in duplicates with the hydrolysates (Table 2) under same conditions as previously described.

18F-TFB was prepared and formulated in sterile 0.9% NaCl under Current Good Manufacturing Practice (cGMP) conditions as previously described [12].

Sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) was performed according to Laemmli's procedure under reducing conditions, as previously reported [14].

H9 hESCs were purchased from WiCell Research, and cultured under standard hESC culture conditions as previously described (Liu et al., 2011).

400 mL seed broth, prepared under the same conditions as previously described, was inoculated into the 5-L bioreactor containing 2.9 L medium.

Rat brains were prepared for cryosectioning under RNAse-free conditions as previously described [21].

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