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These findings suggest that a distinct range or a "sweet-spot" for physiological OSI exists in the mechanical conditioning of tissue engineered heart valves grown from stem cell sources.
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Finally, total RNA and protein obtained from the conditioned group was higher than controls, consistent with a positive effect of CCCM and conditioning on tissue maturation.
Mechanical conditioning of engineered tissue constructs is widely recognized as one of the most relevant methods to enhance tissue accretion and microstructure, leading to improved mechanical behaviors.
We found that the over-representation of disease genes among old genes holds for tissue-specific genes, but the correlation between age and disease association vanished when conditioning on tissue-specificity.
The control system allows full adjustability of operating conditions needed for the growing, conditioning and testing phases of tissue engineered heart valves.
It provides a new and valuable tool that could help to unravel clinically relevant hypoxia-associated mechanisms and to promote a better understanding of ischemic conditioning as well as of tissue hypoxia and ischemia-reperfusion injury.
Higher correlations between expressed genes are an expected result of conditioning on a narrower field of tissue types.
Results therefore support hypotheses relating to increased solute transport as a mediator of the cartilage biological response to dynamic compression, and may have application in mechanical conditioning of cartilage constructs for tissue engineering.
Acid conditioning of dental enamel causes superficial tissue loss that ranges between 20 and 50 μm [7], while a possible removal of the bonded material or the bonded attachment (de-bonding) is associated with additional loss of dental tissue [7], enamel tear-outs [8], or enamel cracks [8].
The observations in BALF support a role for tissue specific microenvironment conditioning of NK cells.
In humans support for tissue specific microenvironment conditioning of NK cells comes from studies of pulmonary sarcoidosis and non-small-cell lung cancer [ 26, 28].
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