Sentence examples for conditionally designed from inspiring English sources

Nonetheless these results indicate that the error due to non-conformity to the aforementioned restriction plays a minor role in the overall model error and that the overall error of the multi-cell models with conditionally designed cells is comparable to the error of finite difference models with much denser discretization.

We designed conditionally replicative adenoviruses based on a specific segment of the SPARC promoter with the aim to target both malignant and tumor-associated stromal cells.

We have previously designed a conditionally replicative oncolytic adenovirus (CRAd) named Ad-F512 that can target both the stromal and the malignant melanoma cell compartments.

We report several RNA and RNA/DNA-based nanoparticles designed to conditionally activate the RNA interference in various human cells.

Targeting vectors were designed to conditionally replace mouse exon 18 with human exon 18, coding for either the 4- or 5-repeat VNTR (Fig. 1 A ).

Also of interest, the Pierce group described "small conditional RNAs (scRNAs)" where a series of RNA-based oligonucleotides (some bases were chemically modified) were designed to conditionally produce a Dicer substrate that can induce RNA interference (RNAi) in response to a trigger RNA.

Here, we designed a new conditionally replicating adenovirus (CRAd) for selective and effective oncolytic replication in HPV-containing cells.

To enable the rearing of the transgenic strain, the female-specific lethal element is designed to be conditionally expressed.

In this work, we modified a previously designed tumor stroma-targeted conditionally replicative adenovirus (CRAd) based on the SPARC promoter by introducing a mutated E1A unable to bind pRB and pseudotyped with a chimeric Ad5/3 fiber (Ad F512v1), and assessed its replication/lytic capacity in ovary cancer in vitro and in vivo.

(6, 7) Among them, virotherapy based on conditionally replicative adenoviruses (CRAd), which are designed to replicate and spread within the tumor to overcome the issue of incomplete in vivo tumor transduction, has a unique advantage compared to the therapy based on a non-replicative system.

(Cancer Sci 2009; 00: 000–000) Conditionally replicative adenoviruses (CRAds) are promising anticancer agents designed to exploit tumor-selective replication followed by lysis of the tumor and lateral spread of viral progeny via infection of neighboring tumor cells.