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Both WT and GluA1−/− mice acquired the discontiguous, non-spatial conditional task (Fig. 4B).
Both WT and GluA1−/− mice acquired the contiguous version of the non-spatial conditional task (Fig. 2B).
BDS facilitates the creation of lazy processing pipelines by means of the dependency operator and conditional task execution (see Listing 1, line 5 for an example).
On completion of this non-spatial conditional task, 20 trials of rewarded alternation testing revealed a spatial working memory deficit in the GluA1−/− mice relative to WT controls (t(11) = 8.8; p < 0.001, Fig. 5).
The successful acquisition of the discontiguous, non-spatial conditional task is also in contrast to the impairment seen on the spatial version in which a start arm floor insert indicated whether the left or right goal arm was rewarded [10].
An apparent exception concerns some biconditional tasks as it has been found that hippocampal lesions can impair an egocentric conditional task that is spared by anterior thalamic damage (Sziklas & Petrides, 2004).
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Examples are visual conditional tasks [ 41,42 ], spatial working memory tasks [ 43,44], oddity tasks [ 45,46] or visual matching and non-matching rules [ 47,48].
It is possible the dissociation is caused by the different types of information used (i.e. spatial/nonspatial) in the conditional tasks.
The same study also found that perirhinal cortex lesions impaired learning the what where but not the what when configural task, leading to the conclusion that the perirhinal cortex is selectively required for those conditional tasks involving visual context.
For example, activation increases in the pre-PMd have been shown during sensory-motor associations tasks, conditional motor tasks, during presentation of visual cues related to specific movements, and during complex working memory, or movement imagination tasks [30], [33].
Behavioral testing was conducted following chelation therapy, from 2 to 9 months of age; this report presents the results of two of the administered tasks: (1) a conditional olfactory discrimination task (baseline task), and (2) a conditional olfactory discrimination task with periodic reward omission on some correct trials (RO task).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com