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They showed that most of these genes differed across environments, which supports the view that local adaptation involves alleles that are beneficial in one environment but neutral elsewhere (conditional neutrality), rather than alleles that are beneficial in one environment and deleterious in another (antagonistic pleiotropy) (Colautti et al. 2012).
However, there is also a great deal of evidence for relaxed selective constraint on many of the R-genes compared to reference genes, which was also found in the R-genes in Arabidopsis thaliana[ 45], a pattern which may be reflective of conditional neutrality of the loci under environmental conditions where the functional gene is no longer adaptive [ 44].
Furthermore, it is possible that local adaptation involves only weak antagonistic pleiotropy or conditional neutrality, where a beneficial allele in one environment has only small deleterious or neutral effect in other environments.
For climate adaptation, the most common genomic pattern is conditional neutrality, as proven by weak across-environment correlations, frequent SNP × environment interactions, and the topology of some developmental and physiological pathways potentially involved in local adaptation.
In other words, conditional neutrality in practice usually means conditional near-neutrality.
Hermisson and Wagner (2004) assumed sexual reproduction and argued that the sex dependence of allelic effects is an important mechanism for conditional neutrality.
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To relax equilibrium assumptions we ask the following: Are TE insertion allele frequencies consistent with neutrality, conditional on the inferred time that has elapsed since insertion?
The "neutrality" conditions are analyzed.
(The conditional is a condition.
Two different classes of decision rules could generate this behavior: rules that are optimal conditional on utility functions departing from risk neutrality, or heuristics derived from limited cognitive processing capacities and satisficing.
Neutrality is a privilege.
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CEO of Professional Science Editing for Scientists @ prosciediting.com