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Of course, the mere claim that the language of science can be extensional still proves troublesome enough, given that in such a language a distinction between laws and accidentally true universal propositions cannot be drawn (the notion of a counterfactual conditional, needed to distinguish the former, is an intensional one).
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This indicates that what looks like a response to secretion stress, may reflect a more general mechanism not only to alleviate accumulation of unfolded proteins in more extreme conditions, but also to modulate secretion capacity in response to the conditional need for extracellular enzymes.
Our study therefore suggests rewiring of molecular interactions driven by gene expression changes depending on the conditional needs.
It is interesting that not all motifs are equally important in a given growth environment, and new patterns emerge depending on the conditional needs.
Transcriptional regulation of protein synthesis and secretory pathway genes may thus reflect a general mechanism for modulation of secretion capacity in response to the conditional need for extracellular enzymes.
Since each of these motifs is required for a classified function depending on the conditional needs, our objective was to understand how the importance of such network motifs varies with growth conditions.
The remainder conditional probabilities needed to compute P(N 1, p B )) are computed in a similar way.
In the text that follows we describe how to estimate the conditional probabilities needed to compute entropy (i.e., uncertainty) and surprise (see the Supplemental Experimental Procedures).
Shell's chief executive, Ben van Beurden, said: "I am delighted we now have all the pre-conditional approvals needed to move to the next important phase.
In Bayesian filtering, the conditional likelihood needs to be known only up to a proportionality factor (see Section 3).
In Additional file 1, we also derive the univariate fully conditional posterior distributions needed for a single-site Gibbs sampler and the fully conditional expected values for GEM.
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