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As shown in Fig. 4 B, PIAS1 knockdown not only enhanced the induction of certain ROS-sensitive genes (RRAD and GADD45A) but was conditional for the regulation of others, such as MCL1 and MDM2, which encode the antiapoptotic BCL-2 homologue Mcl-1 and the potent negative regulator of the p53 tumor suppressor Mdm2, respectively.
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We have performed follow-up experiments that validate conditional regulation by two FFRPs, and demonstrate a context dependent fitness benefit for the regulation.
A strain conditional for the expression of CaMK was created.
Jacob's vow is far too conditional for the rabbis of old.
These measures are conditional for the disbursement of the funds.
We consider the application of a recently developed "conditional integrator" technique for the output regulation of a class of nonlinear systems to process control systems.
2836 for the regulations.
For this, a tet-regulatable copy of the gene is inserted at an exogenous locus in a strain that expresses a copy of the tet-repressor protein that is necessary for the conditional regulation.
MDL approach gave the regulators for each gene and the conditional probability table from which the regulation functions are derived using the approach described in previous paragraph.
Cre/LoxP recombination is the gold standard for conditional gene regulation in mice in vivo.
Functional analysis of essential genes in the malarial parasite, Plasmodium, is hindered by lack of efficient strategies for conditional protein regulation.
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