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The hypothesis of immunodominance being related to low similarity to self is beguiling but there are undoubtedly other concurring factors.
Due to the low IgA concentration in genital fluids [17] and to the concurring factors here summarized, it is reasonable that well-working methods suitable for IgG isolation often fail in retrieving mucosal IgA [18].
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By showing a relationship between peptide similarity and immunodominance we validated low similarity to the host proteome as a concurring factor in the modulation of the pool of epitopic sequences, with a potential role in discriminating immunodominant from cryptic peptides.
The picture becomes more complicated by acknowledging the multiplicity due to the existence of co-factors concurring to gene regulation, to the presence of other sources of variations, like epigenetic events, and by gene regulation compensatory effects.
Osmotic stress caused by the addition of NaCl, low cell growth rate linked to high biomass yield in the properly-designed rich medium, optimization of the time and the amount of inducer's addition and decrease of temperature during recombinant protein production, represent the factors concurring to achieve the reported expression level.
Three factors concur to effective learning: 1. Training set.
All these factors concur in lowering the number, as well as the similarity of repeating features, thus causing an overall reduction of the inlier rate.
Although of relevance, VEGF is not the sole factor concurring to angiogenesis.
Direct neuronal damage caused by hyperglycaemia and downregulation of neurotrophic factors concurs in the pathogenesis of diabetic neuropathy [ 7, 8].
RNA polymerase is essential for transcription (Hurwitz, 1959) and many factors concur to modulate gene expression through the regulation of the binding to DNA of this molecular machine.
Two factors concur to determine specific Rho GTPase function: tissue specificity of GTPase effectors and distinct intracellular localizations of closely related Rho GTPases, due to different lipid modifications [ 1].
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CEO of Professional Science Editing for Scientists @ prosciediting.com