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Concurrently, the expression of genes encoding heat shock proteins (i.e., chaperones) is increased, resulting in the protection of other proteins from denaturation caused by dehydration [35].
Concurrently, the expression of endothelium-derived NO synthase (eNOS), which influences the production of NO is reduced, whilst expression of cytokines and ICAM increases [ 26].
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Concurrently, the expressions of differentiation marker (Tuj1) increased and stemness markers (Snail and Musashi) decreased (Fig. 5b).
It was also found that each of zinc finger protein (AP-4) and E2F concurrently regulates the expression of five genes, and vitamin D (1,25-dihydroxyvitamin D3) receptor (VDR) concurrently regulates the expression of four genes in the normal-specific coexpression network.
In human osteoblasts, parathyroid hormone (PTH) treatment concurrently increased the expression of RANKL mRNA and decreased MMP-14 production [ 42].
The ability to concurrently profile the expression of many genes in a tissue provides a powerful tool for comparing endosperm mutants with their wild-type counterparts to understand their functional role in metabolic processes.
The team, led by Hiroyoshi Toyoshiba of the NIEHS Laboratory of Computational Biology and Risk Assessment, created a statistical software program that verifies concurrently that the expression of one gene is linked to the expression of several others.
RfBP-induced early flowering also correlates with increased expression of FD and AP1 at the shoot apex [ 40], suggesting the role of RfBP in concurrently enhancing the expression of flowering-related genes assigned to photoperiod, floral regulation, and FMI categories.
The role of NANOG is thus to build a naive pluripotent transcriptional network by concurrently inducing the expression of ESRRB, enhancing LIF/STAT3 signal transduction, and inducing KLF4 expression in cooperation with pSTAT3.
It was found that each of hsa-miR-504 and hsa-miR-125a concurrently regulates the expression of four genes in the normal-specific coexpression network, forming two MRSs.
We therefore generated human dendritic cells analogous to the ones successfully used in those NOD studies (6), concurrently targeting the expression of the same costimulatory molecules ex vivo, envisaging type 1 diabetes cell therapy.
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