In this type of malignant cells, plectin translocates to the cell membrane, whereas in non-tumor cells, plectin is restricted to the cytoplasmic compartment; concurrently, expression of plectin increases with tumor progression and metastasis (Bausch et al. 2009, Bausch et al. 2011).
Metastatic epithelial cancers such as colon cancer re-activate expression of mir-200c gene in growing metastases concurrently with high expression of the targets ZEB1 and JAG1.
We therefore generated human dendritic cells analogous to the ones successfully used in those NOD studies (6), concurrently targeting the expression of the same costimulatory molecules ex vivo, envisaging type 1 diabetes cell therapy.
A second screen for small molecules that promote the conversion of definitive endoderm into pancreatic progenitors was concurrently undertaken, using expression of the pancreatic marker Pdx1 as an indicator of differentiation efficiency (124).
Concurrently, the expression of endothelium-derived NO synthase (eNOS), which influences the production of NO is reduced, whilst expression of cytokines and ICAM increases [ 26].
Concurrently, the expression of genes encoding heat shock proteins (i.e., chaperones) is increased, resulting in the protection of other proteins from denaturation caused by dehydration [35].
In the case of drugs from which a specific antigen response is expected as the mechanism of action, it is important to concurrently develop a method of measuring expression of the target antigen in the cancer tissue of individual subjects, etc. and consider the possibility of using this data in immune reaction monitoring and subject selection.
It was concluded that the enhanced DC migration was due to the elevated matrix metalloproteinase production and the concurrently diminished expression of inhibitors of metalloproteinase (Darmanin et al, 2007).
2) In the zebrafish experiments, SPOP knockdown leads to cell death concurrently with induction of p53 mRNA and induced expression of the p53 target genes MDM2 and CCNG1.
Viral replication and expression of the recombinant fusion gene occurred concurrently in agroinfiltrated N. benthamiana.
