Sentence examples for concurrent knockdown from inspiring English sources

Moreover, double knockdown studies showed that the accumulation of the polyadenylated U1 transcripts in NELF knockdown cells was reversed by concurrent knockdown of CPSF-73 or CstF-64 (Fig. 5b), suggesting that NELF prevents CPSF- and CstF-mediated cleavage and polyadenylation of U1 transcripts.

By contrast, the concurrent knockdown of EGFR with Stat3 inhibition (by S3I-201) [25], or the concurrent knockdown of Src with Stat3 inhibition, or the concurrent EGFR knockdown with Src inhibition (by Das) resulted in a strong suppression of c-Myc expression (Fig. 6C ii)).

Given the correlation between CCNE1 and TPX2 amplification, we also examined whether concurrent knockdown of both genes would further diminish viability in cell lines containing both amplifications (Figure 8C).

Concurrent knockdown of these three factors leads to neural cell death and abrogates neuronal development.

In contrast concurrent knockdown of dhhc-4 and spe-10 resulted in an increase in mean and median lifespan.

This p21 increase is p53-dependent since no increase in p21 protein levels was detected upon concurrent knockdown of HdmX and p53.

Moreover, the ten-a phenotype was not enhanced by concurrent RNAi knockdown of α-spectrin in ORNs, suggesting that Ten-a and α-spectrin function in the same pathway to regulate olfactory synapse number.

We then proceeded to assess the effect of Par-4 knockdown concurrent with exogenous TGF- β treatments to determine whether Par-4 was necessary for TGF- β to induce EMT characteristics.

As expected, there was a dramatic reduction in NRP-1 immunoreactivity, confirming the efficiency of the knockdown, concurrent with a distinct decrease in both PDGFRα-Tyr and PDGFRβ-Tyr immunoreactivity.

Concurrent treatment of NPC1 knockdown mice with anti-TNF had no effect on the primary lipid storage or accumulation of lipid-laden macrophages.

However, TU7 was intriguing because its knockdown led to approximately 30% concurrent reduction in Klf4 and Nanog levels, as well as to 1.5-fold upregulation of Fgf5 and T-brachyury.