Exact(23)
T cells are activated by the concurrent induction of the T cell receptor (TCR) and one or more costimulatory receptors.
One central question concerns the mechanism by which CTLA-4 can induce T-cell non-responsiveness without a concurrent induction of antigen induced cell death (AICD).
Over-expression of Syncytin-1 in astrocytes causes an unfolded protein response resulting in endoplasmic reticulum stress; there is also ensuing neuroinflammation with concurrent induction of interleukin-1β and NOS2 [19].
Exercise led to early transcriptional changes in striated muscle activator of Rho signaling (STARS), Rho family GTPase 3 (RND3), mitogen activated protein kinase (MAPK) regulation and the downstream transcription factor FOS. Targeted RT-PCR analysis identified concurrent induction of negative regulators of calcineurin signaling RCAN (P<0.001) and HMOX1 (P = 0.009).
It agrees well with the fact that DNCB as well as juglone are compounds that target and inhibit cellular TrxR1 with concurrent induction of a cell death, showing necrotic features but also involving caspase-3/7 activation and being strikingly different in properties compared to the cell death triggered by staurosporine [52].
Statins mediate their action via suppression of Th17 differentiation with the concurrent induction of Treg differentiation.
Similar(37)
In this manuscript, we report hemodynamic and thermokinetics measured in a highly instrumented swine model of prolonged CPR with concurrent hypothermia induction.
After 10 min of untreated ventricular fibrillation, mechanical chest compressions were provided for 60 min (100 CPM, 1.25" deep) in 26 domestic swine (30.5 ± 1.7 kg) with concurrent hypothermia induction using one of eight cooling methods.
Of these, 47 had chemoradiotherapy (35 concurrent, 12 induction) and 24 had radiation alone.
Concurrent or induction chemotherapy slightly improves the figures; median survival is marginally improved in randomized trials (Marino et al, 1995).
Consistent with a role for NMDARs in MDD, inescapable stress has been shown to lead to disruptions in NMDAR-dependent synaptic plasticity concurrent with induction of behavioral depression-like behavior (Trullas and Skolnick, 1990).
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