Sentence examples for concurrent dosing from inspiring English sources

Concurrent dosing with ANF protected against the VCD-induced follicle loss in rats, but not in mice.

Since cytotoxic agents preferentially target proliferating tumour cells, the continuous concurrent dosing of axitinib in combination with cytotoxic agents may inhibit the activity of the cytotoxic agents.

Concurrent dosing with cyclosporine (a CYP3A4 substrate) following anidulafungin 100 mg/day demonstrated no significant alteration in pharmacokinetics of either drug (Dowell et al. 2005).

When axitinib was combined with gemcitabine in a pancreatic xenograft model and with paclitaxel plus carboplatin in a xenograft model of non-small-cell lung cancer (NSCLC), tumor growth inhibition was highest with concurrent dosing of antiangiogenic and chemotherapy [ 23].

Such clinical chronopharmacologic development of gemcitabine-platinum combination is warranted in view of both the limited efficacy of current treatment regimens in advanced lung cancer and the three-fold survival benefit achieved here by the optimal circadian schedule as compared to concurrent dosing of both agents in the experimental model.

Although concurrent dosing of selumetinib and docetaxel is highly effective in pre-clinical models (Haass et al, 2008) in view of the role of MAPK in the cell cycle and in particular involvement in mitotic entry/progression, we wanted to understand whether there was any benefit from the scheduling order of selumetinib with docetaxel dosing.

In the absence of S9, meaningful measurements were impossible on account of a concurrent dose dependent increase of toxicity.

In addition to mean revertants and fold increases (compared to air controls), QCM deposition data was obtained during whole smoke exposure for concurrent dose measurements.

These improvements were observed despite significant concurrent dose-dependent increases in the average voiding interval in the duloxetine groups compared with the placebo group.

For this purpose, use a concurrent dose of an immediate-release formulation of the same opioid.

In two patients only (patients 10 and 11), dose-response curves were characterized by a concurrent dose-dependent decrease in MPAP and an increase in PaO2/FiO2 in the range of 0.15 to 150 ppm inhaled NO.