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In the absence of S9, meaningful measurements were impossible on account of a concurrent dose dependent increase of toxicity.
In addition to mean revertants and fold increases (compared to air controls), QCM deposition data was obtained during whole smoke exposure for concurrent dose measurements.
For this purpose, use a concurrent dose of an immediate-release formulation of the same opioid.
Also, there was no evidence of nonlinearity of pharmacokinetics as the dose of temozolomide was increased and no effect of increasing the concurrent dose of paclitaxel from 150 to 225 mg m−2.
Four treatment schedules were tested: 72 h concurrent, 72 h inhibitor followed by 72 h chemotherapeutic, 72 h chemotherapeutic followed by 72 h inhibitor, and a 144 h concurrent dose with a media change at 72 h (similar to the sequential treatments).
Overall, the toxicities of the concurrent combination of RTx and sunitinib administered in 6-week cycles appears to depend on the duration and dose of sunitinib treatment, on the concurrent dose of RTx, but also on previous chemoradiation and type of metastases, e.g., liver or brain.
Similar(54)
These improvements were observed despite significant concurrent dose-dependent increases in the average voiding interval in the duloxetine groups compared with the placebo group.
Concurrent dosing with ANF protected against the VCD-induced follicle loss in rats, but not in mice.
In two patients only (patients 10 and 11), dose-response curves were characterized by a concurrent dose-dependent decrease in MPAP and an increase in PaO2/FiO2 in the range of 0.15 to 150 ppm inhaled NO.
The concurrent dose-dense regimens were associated with more red-cell transfusions, more grade-3 emesis and more post-chemotherapy neurotoxicity than the sequential approach, all of which may be particularly relevant in older patients.
Since cytotoxic agents preferentially target proliferating tumour cells, the continuous concurrent dosing of axitinib in combination with cytotoxic agents may inhibit the activity of the cytotoxic agents.
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