Three of these loci had concordant effect size and direction in an independent sample of 656 adult EA participants of the Health, Aging, and Body Composition (Health ABC) Study.
Observed and expected fragment profiles were highly concordant for sizes over 150 bp (see Additional file 2).
Existing SRM programs report an indel as soon as two independent reads support the same SV, and if their partner reads lie within concordant insert sizes [ 22, 23].
Classical HLA alleles imputed to four-digit resolution using either HLA-IMP*02 or SNP2HLA in ALSPAC showed concordant effects sizes (Supplementary Material, Fig. S4).
All oocyte donors (age 18 35 years) had normally appearing ovaries at transvaginal ultrasound, an antral follicle count >8, and displayed a correct response to ovarian stimulation, i.e. a progressive and gradual increase in follicular sizes, concordant with FSH administration.
Effect sizes of local-eQTLs in F2 and HMDP yielded highly concordant results, while effect sizes of ASE have poorer correlation to effect sizes observed in local-eQTLs (Additional file 1: Figure S8A-C).
The reduction in platelet numbers and the concordant increase in platelet size were even more pronounced when analyzed at 1 year of age.
These include the strontium [ 161], intensive weight-loss therapy [ 162] and glucosamine [ 163] trials, and some of these describe a concordant reduction in BML size and cartilage volume loss.
For all matepairs, if any pair of BLAT hits for its two reads were concordant with the insert size (mapped at a distance <2σ from the mean), the clone was considered to be supported by the genome, and was discarded from clustering analysis.
In tomato, Städler and colleagues [ 117] investigated the historical demography of wild tomatoes and demonstrated that the closest wild relative species exhibit concordant signatures of population-size reduction during the evolutionary history.
