Exact(1)
These three regimens offered the highest rates of adequate coverage (93%to95%5%), and only one non-guideline concordant regimen (vancomycin/ciprofloxacin) offered as high a likelihood of adequate coverage (93%) (Table 4).
Similar(59)
Among the 14 non-guideline concordant dual-therapy regimens studied, the average rate of adequate coverage for VAP was 87%, and many offered rates of adequate coverage similar to the guideline concordant regimens (Table 4).
In addition, the MOXIRAPID study primarily compared antibiotic regimens that are not considered guideline-concordant for severe CAP, and nowhere in the report presenting the results of the study [ 6] can we find separate information on the patients who were treated with erythromycin and ceftriaxone (which would be the only guideline-concordant regimen for severe CAP studied).
Although 71% were aware of published guidelines, participants chose guideline-concordant antibiotic regimens for HCAP only 9% of the time.
See related research article I read with interest the report by Mortensen and coworkers [ 1], who found the use of initial empiric antimicrobial therapy with a β-lactam and a fluoroquinolone to be associated with increased short-term mortality in patients with severe community-acquired pneumonia (CAP) compared with other guideline-concordant antimicrobial regimens.
In contrast, WISCA calculations for VAP indicated that many non-guideline concordant dual-therapy regimens were just as likely as guideline concordant dual-therapy regimens to provide adequate VAP coverage [ 9].
The regimen was concordant with the recommendation of the German guidelines for the management of preterm labour [ 15].
The drug regimen was concordant with the German guidelines for the management of preterm labour, with two alternative modalities of fenoterol analysed: continuous or bolus administrations.
Others have simply determined whether an antibiotic regimen that was concordant with formal treatment guidelines was given.
In so doing, this study goes beyond traditional guideline-concordant studies by examining antibiotic dose and regimen, rather than antibiotic choice alone.
We also calculated the percentage of adequate coverage offered by the subset of dual-therapy regimens that would have been considered concordant with the Canadian VAP treatment guidelines [ 9] or the Infectious Diseases Society of America (IDSA) CRBSI management guidelines [ 10].
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com