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Only hexadecanedioate showed concordant direction of effect for both BP and mortality, while in contrast, the direct association between dihomo-linoleate(20 2n6) or caffeine and blood pressure did not translate into increased mortality risk.
Fourteen genes demonstrated consistent changes in gene expression (concordant direction of fold-change) by qRT-PCR when comparing mild and moderate COPD samples.
(2009) were differentially expressed with concordant direction in N. furzeri (Table S9 and Fig. S12).
Their diagnostic signature is composed of 13 miRNAs, five of which overlap with our signature, with concordant direction of variation (upregulated or downregulated).
Additionally, all other lines carrying introgressions at the same bin (corresponding to qVgt-9.03/4 qVgt-9.03/4oncordant direction of genetic effect (aIL = 0.5 cm; P < 0.10).
To ensure replication, an additional criterion was that each metabolite was nominally significant (P < 0.05) in both cohorts with concordant direction of effect.
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The aim of this analysis was to evaluate the aggregate effects of many SNPs of small effect and assess whether subsets of SNPs selected in this manner from one disease/trait GWAS predict disease/trait status in another, thus providing a measure of a common polygenic component with concordant directions of effect underlying the traits.
'Replication' was determined as concordant effect direction and nominal significance (P < 0.05) in the Health ABC Study.
At the 1.5 and 2-fold threshold level, the agreement between platforms approaches 100% indicating that for reproducible data all three platforms are highly concordant in direction.
Of the three SNPs investigated with severe CP, one SNP (NPY locus: rs2521634) was nominally associated with severe CP in the Health ABC Study ORR = 1.64; 95% CI = 1.01 2.65; P = 0.046), with a concordant effect direction and magnitude as in ARIC (Table 3).
Although no signals met genome-wide significance criteria, we found that three of these loci (NPY, NCR2 and EMR1) had concordant effect direction in a replication sample, with NPY being nominally associated with severe CP.
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