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The genes showing concordant association signals of GWAS, QTT and eQTL are promising candidate genes.
We found that 8 out of 11 SNPs showed concordant association directions between the two phenotypes (Table 2).
Despite this acknowledged limitation, ERCC1 expression by FL297 and 4F9 demonstrated strong and concordant association with PFS in this study.
Only DDS, but not MDD or CES-D, displayed a significant time concordant association with A1C (b = 0.024, P = 0.001).
In addition, we performed survival analysis on other dicarboxylic acids (tetradecanedioate, octadecanedioate, and dodecanedioate) and none of them showed significant concordant association with mortality.
After comparing the association direction for clinical overall survival with that of the LCL results, 8 out of 11 SNPs showed concordant association directions between the two phenotypes.
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Concordant associations between CCL3L1-CCR5 genotype and recovery of CD4+ T cell counts were also observed in subjects who received HAART during acute/early infection [23].
Positive epistasis arises under concordant associations (Δ iΔ j > 0), implying higher rates of gene flow (redder regions).
These analyses provided statistical information only about the degree of time-concordant association between changes in a characteristic and changes in A1C over time; they did not provide information about the causal linkages between the two.
In summary, we found no cross-sectional, prospective, or time-concordant associations between MDD and depressive symptoms with glycemic control, whereas significant cross-sectional and time-concordant relationships were found between diabetes distress and glycemic control.
Therefore, the results of our study are concordant with previous studies, which did not corroborate the association between the analyzed SNPs and smoking initiation either, yet they demonstrated the association existing for ND severity [ 17].
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