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Data concordance was evaluated via Deming regression analysis.
For each platform pair, genotype concordance was evaluated between all observed SNPs and all imputed SNPs.
Epidemiological concordance was evaluated by testing isolates related to two different outbreaks with the MOL-PCR assay.
Data entry concordance was evaluated using haemoglobin and blood pressure levels at emergency department arrival, Injury Severity Score (ISS), and mortality.
Genotype concordance was evaluated between the Affymetrix 6.0 and OmniExpress, as well as between these two platforms and a third genotyping platform, the Immunochip.
For the purposes of network model construction, each scored HYP meeting the minimum statistical cutoffs for richness and concordance was evaluated and selected for integration based on its biological plausibility and relevance to the perturbation and biological context (eg, cell type) of the experiment applying a manual curation process.
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For the purposes of network model construction, top scoring HYPs meeting the minimum statistical cutoffs for richness and concordance were evaluated and selected for integration based on their biological plausibility and relevance to the perturbation and biological context (eg, cell type) of the experiment.
Following automated hypothesis generation (which can generate hundreds of hypotheses for a given data set analysis), each scored hypothesis meeting the minimum statistical cutoffs for richness and concordance is evaluated and prioritized by a group of scientists based on its biological plausibility and relevance to the experimental perturbation used to generate the data.
The concordance pattern was evaluated using both the unweighted and the weighted kappa statistics; the strength of agreement was as follows: <0.00 = poor agreement, 0.00 0.20 = slight agreement, 0.21 0.40 = fair agreement, 0.41 0.60 = moderate agreement, 0.61 0.80 = substantial agreement, and 0.81 1.00 = nearly perfect agreement [ 13].
Concordance of measures was evaluated using CCC.
Concordance among solutions was evaluated using the Cohen's kappa coefficient k.
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