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Silman, A. J. et al. Twin concordance rates for rheumatoid arthritis: results from a nationwide study.
Concordance rates for PD or parkinsonism were somewhat higher but the heritability estimate was nonsignificant.
First, all the WGS datasets achieved high concordance rates of the genotypes with those genotyped by SNP microarrays31,32 (≥99.97%), which provides confidence in calling of common variants.
Moreover, the low concordance rates for most autoimmune diseases suggest that epigenetics contribute to immune tolerance disturbance.
Other probe design strategies averaged substantially lower call rates (94.65 96.41%) and slightly lower concordance rates (99.64 99.80%).
RESULTS: Item-level concordance rates ranged from slight to fair.
Genetic liability is further supported by concordance rates in twins [5] and familial aggregation [6].
The concordance rates in MZ twin pairs were less than 100%.
The concordance rates are in percentage and the 95% confidence intervals are in parenthesis.
Concordance rates for migraine are consistently higher among monozygotic (MZ) than dizygotic (DZ) twins.
The concordance rates of plasma with tissue-based results of EGFR mutations were 87.9% for L858R and 86.2% for ex19del.
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